luni, 14 februarie 2011

Aloe

Overview:

The Aloe vera plant has been used for thousands of years to heal a variety of conditions, most notably burns, wounds, skin irritations, and constipation. It is grown in most subtropical and tropical locations, including South Africa, Latin America, and the Caribbean. Aloe was one of the most frequently prescribed medicines throughout most of the 18th and 19th centuries and it remains one of the most commonly used herbs in the United States today. However, oral use of aloe for constipation is no longer recommended, as it can have severe side effects.
 Curing Stomach Ulcers with Aloe Vera

 
The following information is for humans with Ulcers of the Stomach

Introduction to Ulcers of the Stomach

Stomach Ulcers are holes in the stomach lining often caused by a build up of Acid. It is dangerous to surpress the pain and ultimately the ulcer must be repaired
Aloe Vera has long been known as a powerfully soothing salve for the skin. It is now well known to be wonderful for healing cuts, scrapes, and burns. But did you also know that aloe vera just as effective with wounded interior skin? Aloe vera juice, when taken internally, can soothe the most irritated stomach conditions – even those as severe as peptic ulcers. Peptic (also known as gastric) ulcers, are open sores in the caused by digestive juices and stomach acid. No one knows for sure what brings on these often painful episodes, but stress, not surprisingly, is often a trigger.
People often make the mistake of using the misleadingly soothing appearing smooth white yogurt made from cow’s milk to treat ulcers. Unfortunately, the lactic acid in yogurt actually worsens the condition.

Peptic, Duodenal, Colon and Intestinal Ulcers Relief

As we all know, ulcers  are everywhere. Any break in the skin, which refuses to heal in a  normal length of time, is commonly referred to as an ulcer. Most ulcers  caused by external trauma such as wounds, lesions, scraps and burns will  normally heal over time if kept clean and are exposed to clean air and  oxygen.

Irritable bowels
 
Researchers at Morriston Hospital, Swansea, are conducting trials to establish whether aloe vera is an effective treatment for irritable bowel syndrome (IBS).

Can Aloe Vera cure, help, treat or prevent Ulcers of the Stomach?

Using Aloe Vera for Ulcers of the Stomach



Start drinking a very small amount of high quality Aloe Vera Gel (say 1 teaspoon) 3 or 4 times a day. Slowly build this up to 3 or 4 tablespoons, 3 or 4 times a day on an empty stomach. This build up could take days or weeks, it is up to the sufferer to decide.

Once the pain has subsided continue to take a 'maintenance dose' of 2 tablespoons, twice a day on an empty stomach to avoid ulcers returning.


How long will it take for Aloe Vera to work with Ulcers of the Stomach?

As a very general rule of thumb allow one month for every year the ulcers have been in the stomach although recovery time will depend on the number of Ulcers, how extreme they are and the general state of health and diet.


Aloe Gold Seal

All-in-One Health Benefits

When it comes to polysaccharide chains, size matters. This is because each polysaccharide size range not only contains the traits and health benefits asscociated with that particular weight range, it also includes the benefits associated with each weight range below it. The four polysaccharide chain size categories below lists the health benefits that accumulate from the SMALL to VERY LARGE:

All-in-One Health Benefits
  1. SMALL (Under 50,000 Daltons) 12 - 14% is absorbed and may aid in:
    • DIABETES (Type 1 and Type 2) - reduces blood sugar levels in human as well as animal studies, even in the absence of insulin.
    • ANTI-INFLAMMATORY
    • ARTHRITIS
    • COLITIS - may protect against or reverse these serious inflammations of joint linings and the colon.
  2. MEDIUM 50,000 - 150,000 Daltons that may aid in:
    • ANTI OXIDANT - Have very potent anti oxidant properties but, unlike drugs, do not interfere with normal functions of cells and
    • ALL OF THE BENEFITS ASSOCIATED WITH SMALL POLYSACCHARIDES
  3. LARGE 150,000 - 1,000,000 Daltons that may aid in:
    • ANTI BACTERIAL
    • HEALING PROPERTIES and
    • ALL OF THE BENEFITS ASSOCIATED WITH SMALL AND MEDIUM POLYSACCHARIDES
  4. VERY LARGE > 1,000,000 Daltons 4 - 5 % are absorbed and may aid in:
    • SUPPORT / IMPROVE IMMUNE SYSTEM FUNCTION and
    • ALL OF THE BENEFITS ASSOCIATED WITH SMALL, MEDIUM AND LARGE POLYSACCHARIDES

Burns
Aloe gel, made from the central part of the aloe leaf, is a common household remedy for minor cuts and burns as well as sunburns. It can be found in many commercial skin lotions and cosmetics. Aloe contains active compounds that may decrease pain and inflammation and stimulate skin growth and repair. For this reason, aloe vera gel has gained tremendous popularity for relief of burns, with individual success in helping minor burns. In a review of the scientific literature, researchers found that patients who were treated with aloe vera healed an average of almost 9 days sooner than those who weren't treated with the medicinal plant. However, other studies show mixed results, including at least one study that found aloe actually delayed healing. Aloe is best used for minor burns and skin irritations, and should never be applied to an open wound.

Benefits Aloe Vera Active Components SymphonyHistory has shown that Aloe Vera as dietary supplement

Herpes and skin conditions
Preliminary evidence also suggests that aloe gel may improve symptoms of genital herpes and certain skin conditions such as psoriasis. In fact, one study found that aloe vera gel displayed anti-inflammatory effects superior to 1% hydrocortisone cream or a placebo gel. As such, researchers claim that aloe vera gel may be useful in the treatment of inflammatory skin conditions, such as ultraviolet-induced erythema.




Constipation
Aloe juice or aloe latex, a yellow, bitter liquid derived from the skin of the aloe leaf, is a powerful laxative. However, it can cause painful cramping and is not recommended. Other gentler, herbal laxatives from the same plant family as aloe (such as cascara and senna) are generally recommended first.


Aloe Vera IC Study

F

Diabetes
Preliminary studies suggest that aloe juice may help lower blood sugar levels in people with type 2 (adult onset) diabetes. More research is needed to determine whether aloe is helpful for diabetes.

Plant Description:

Aloe vera is a perennial, succulent plant (meaning its leaves hold large quantities of water). The plant can grow up to 4 feet tall, and its tough, fleshy, spearlike leaves can grow up to 36 inches long. The clear, thick gel found in the inner part of the leaf is most commonly used for minor cuts and burns.

What's It Made Of?:

Although aloe is 99 percent water, aloe gel also contains substances known as glycoproteins and polysaccharides. Glycoproteins speed the healing process by stopping pain and inflammation, while polysaccharides stimulate skin growth and repair. These substances may also stimulate the immune system.

Available Forms:

You can get aloe by simply breaking off leaves of the plant (which can be grown as a houseplant), but it is also available commercially in ointments, creams, and lotions. Aloe gel is often included in cosmetic and over-the-counter skin care products as well. You can purchase aloe in the form of capsules, tablets, juice, gel, ointment, cream, and lotion.

How to Take It:

Pediatric
Pure aloe gel may be applied to the surface of the skin for minor skin irritations.
Adult
Slit the leaf of an aloe plant lengthwise and remove the gel from the inside, or use a commercial preparation. Carefully clean affected area and then apply aloe gel liberally to the skin. Do not apply to open wounds.

Precautions:

The use of herbs is a time-honored approach to strengthening the body and treating disease. Herbs, however, can trigger side effects and can interact with other herbs, supplements, or medications. For these reasons, you should take herbs with care, under the supervision of a health care provider.
Aloe gel is considered safe when applied to the surface of the skin, but should not be applied to open or deep wounds. In rare cases, it may cause an allergic reaction, mainly a skin rash. If you develop a rash, stop using the gel.
Taking aloe latex orally may cause severe intestinal cramps or diarrhea and is not recommended. Pregnant women should never take aloe latex because it may cause uterine contractions and trigger miscarriage. Nursing mothers should not take aloe latex either because the effects and safety for infants and children are not known.

Possible Interactions:

If you are currently being treated with any of the following medications, you should not use aloe vera without first talking to your doctor:
Medications for diabetes -- The combination of aloe vera and glyburide, a medication used to treat type 2 diabetes, may help control blood sugar and triglyceride (fat) levels in the blood. People with diabetes who use aloe latex either alone or in combination with other medications must be monitored closely by their doctor to make sure blood sugar levels don't fall too low (a condition called hypoglycemia).
Hydrocortisone -- Aloe gel may enhance the ability of hydrocortisone to reduce swelling.
Digoxin and diuretics -- Because taking oral aloe can decrease levels of potassium in the body, aloe latex should not be used by people taking diuretics (water pills) or digoxin (a medication used to treat irregular heart rhythms and congestive heart failure). These drugs also lower potassium levels in the body, so a combination of aloe and digoxin or diuretics could cause potassium levels to fall too low.

Alternative Names:

Aloe vera

Q: Why are Aloe Life Aloe Vera Juices the best available Aloe Vera on the market?
A: Using the entire Whole Leaf of the plant, cold processed concentration 3:1, along with fresh juice not powdered reconstituted- with NO WATER ADDED, certified organic Aloe Life gives the consumer the strongest Aloe Vera product for the best price! The flavored concentrates are delicious for children and adults. The quality of the juice taken determines the results achieved. Satisfaction Guaranteed!

Q: How did the Aloe Life company begin?
A: A clinical nutritionist, Karen Masterson-Koch began researching Aloe Vera in her practice 12 years ago. She began seeing remarkable results with her Cancer, HIV, Chronic Fatigue and all patients upon their use of a quality Whole Leaf Aloe Vera juice. The potency of the products on the market were so low that a patient had to spend too much money to achieve the potency needed to greatly effect ones health. That led Mrs. Masterson to formulate the Aloe Life products, that so many individuals benefit from by daily use today.

Q: Are the flavored Aloe Life juices therapeutic?
A: Most definitely! The Cherry Cranberry, Whole Leaf Aloe Vera Juice Concentrate, was actually the first product introduced onto the market from Aloe Life. This was because Mrs. Masterson wanted all people to be able to enjoy the value the Aloe Vera plant has to offer and many people would not drink the natural Aloe juice. The potency is only 7% less Aloe and tastes delicious. Flavors do not contain sweeteners! Children and individuals of all ages drink and enjoy Aloe Life!

Q: Most people don't even know that you can drink Aloe! Is there any harm from drinking the Aloe vegetable juice?
A: No. Being a vegetable it is best to drink a small amount at first or test the topical Skin Gel on a small area of skin to make sure you are not allergic to Aloe. This is rare yet people can be allergic to natural foods such as strawberries and it's wise to check before using any quantity of Aloe Life. Once you have done the allergy test you may build up to the desired amount of 1-8 oz.. The Aloe Life aloe products actually have a collagen strengthening effect that helps to reduce over all allergy response. Other companies sometimes use sulfites to help retain the color of their Aloe juice. Aloe Life does not use any sulfites and people who cannot tolerate other brands of Aloe juice have done brilliantly with Aloe Life.
Also please see the Health Products section of the web site to learn about the 4 year study that showed no toxicity from Aloe and in fact it lengthened life by 25% according to the researchers. Contrary to other written references, aloe is excellent for children, adults and seniors. Pet lovers use our juice for animals as well!

Q: Why do Physicians tell parents that Aloe Vera is dangerous for children to drink?
A: Their reference is to laxative Aloe Vera products.  Properly processed Aloe Vera juices like Aloe Life are 100% safe and are not formulated to act as laxatives but do provide gentle help moving the bowels. If diarrhea occurs cut back on the amount of juice consumed.

Q: Why do some health books say seniors and pregnant women should not take Aloe Vera?
A: Their reference is to laxative Aloe Vera products see previous ans. regarding laxative Aloe. Their is no harmful or dangerous element in the Aloe Vera plant that will hurt the fetus or the elderly! In fact Aloe Vera is extremely beneficial to seniors because studies have shown that stomach acids naturally decline with age. Aloe Vera helps to regulate the stomach acids providing great support to digestive function. Elderly also receive skin renewal properties through collagen support and increased wound healing. Individuals may feel vigorous and energized because of the many nutrients and electrolytes in Aloe. Pregnant women may experience less nausea and the aloe will encourage milk production!

Q: What is the potency of the Whole Leaf Aloe Vera Concentrate?
A: 14,000 - 21,000 mgs. per liter of MPS or solids\polysaccharides as it has been referred to. Many of the regular Aloe Vera juice products on the market test in the 1,000 - 2,000 range and even lower than this! It varies according to how much water is actually in the formula. Be aware that water is not always included in the ingredient list. Aloe Life tests our juice yearly at an independent laboratory and receives the  proper third party documentation. (Most other Aloe companies do not test their product potency at all. Some will type up results on their own letter head or the company they purchase their aloe from, which is not to be trusted.)

Q: How can a consumer know the quality of an Aloe Vera juice without elaborate testing?
A: Aloe Life documents not only the potency yet also the freshness with 3 microbial tests on every batch. This documents the quality of the juice you are drinking so you feel safe to even give it to your child. It meets the strictest of manufacturing; Good Manufacturing Practices (GMP) with laboratory tests to prove it. Many juices are processed out of the country and do not run the strict testing that Aloe Life insists on. Lastly a consumer looks for the health results they are hopeful for. Aloe Life is effective where many products just hint at support. Best to use Aloe Life for at least three months to test the effectiveness. All of our products come with a 100% Satisfaction Guarantee!

Q: Does the Whole Leaf juice contain more active ingredients than inner gel?
A: Yes. The entire leaf may contain as many as 200 active elements not available in the inner gel alone that support health according to Dr. Robert Davis, Ph.D., microbiologist and renowned Aloe Vera researcher. The valuable yellow sap is only found in whole leaf Aloe Vera products. Note: Many companies filter out all of the yellow sap even if Whole Leaf is indicated.  Aloe Life leaves the highest allowable level of yellow sap in our products providing many benefits to an individual including anti bacterial, anti-fungal, anti-inflammatory, anti-tumor and digestive support.

Q: Why are Aloe Life juices concentrated?
A: Aloe Life wanted to bring to market the most affordable product with the most benefit. To accomplish this we remove natural occurring water from the leaf.(3 qts of water are removed from 4qts of aloe = 1 qt of 3:1 concentrate) This enables Aloe Life to concentrate without high heat.  Aloe Vera is a succulent with 99% of the juice being water and 1% containing the 200 beneficial solids or active ingredients. Therefore by concentrating it costs the consumer less money for more value.

Q: The Aloe Life juices contain vitamins, minerals, enzymes, amino acids, polysaccharides and more. Do we need to take our supplements along with the juice?
A: Yes. Aloe Life juices do contain hundreds of nutrients yet they do not replace the need for supplements. What has been presented in some Research, is that when Aloe Vera juice is taken with other nutrients the absorption increases even up to ten times greater. So it is possible to not only optimize your own digestion of foods yet also any other vitamins or herbs you may take! A recent study conducted at the University of Pennsylvania in 2002 showed 300% better absorption of Vitamins C & E when taken with Aloe Vera Juice.

Q: Even though Whole Leaf Aloe Vera Juice Concentrate is a very strong Aloe Vera by Aloe Life you add extra trace minerals. Why are Trace Minerals so important?
A: Trace minerals are necessary for many metabolic actions within our bodies? Scientist have only just begun to understand the value the trace minerals perform in keeping human beings healthy. Zinc, selenium and molybdenum are just a few of these very important trace minerals that support immune function and energy within the cell. Most people do not eat enough vegetables and whole grains to receive enough minerals from their diets to optimize their health. At no extra cost to the consumer, Aloe Life adds trace minerals to give extra health support without toxicity. Minerals supply electrolyte fuel during the hot weather. Aloe Life helps maintain energy through even the most humid of days!

Q: What is a good dosage to consume of Aloe Life juices?
A: One ounce daily equal to 2 tablespoons is an amount that many people find great as a maintenance amount taken before breakfast is best. Adults can gradually build up to 8 ounces if so desired. The average amount being 2-3 ounces daily. Children Take 1-3 ounces keeping in mind that a larger body size will demand more juice daily, to achieve the desire support. If loose bowels occur, cut back until normal bowel habits return. Many people welcome the encouragement for regularity without diarrhea. If one has a tendency for diarrhea begin with just 1 teaspoon or a capful and increase as the bowels allow. Irritable bowel has an adjustment with taking a quality Aloe and many claim that Aloe was just what was needed to reduce all symptoms. See for yourself!

Q: Does the juice need refrigeration?
A: Yes. If left out of the refrigerator for short periods it is OK. Yet we do not high heat pasteurize the juice so to prolong the freshness refrigerate and avoid drinking directly out of the bottle unless you are using it up quickly. Aloe Gold tablets by Aloe Life are wonderful for traveling and do not require refrigeration.

Q: Are the Aloe Life juices organic?
A: Yes, all of the products are certified organic and pesticide and herbicide free. Being processed in Texas, not from Costa Rica or Venezuela, we guarantee that no harmful chemicals are sprayed on the Aloe Life Aloe Vera.

Q: What preservatives do the Aloe Life juices contain?
A: The food grade preservatives Sodium Benzoate and Potassium Sorbate used in our juices in quantities less than .025 mg per bottle are safe and only retard mold from developing. Just like whole grain bread that molds easily we take every step to ensure a safe and fresh product. Individuals who prefer Aloe Vera with no preservatives may choose our Aloe Gold tablets. They do not require mold inhibitors or citric acid and are the finest Aloe Vera in a tablet available (3 tablets = 1 oz of juice concentrate).

Q: When is the best time to take Aloe Life juices?
A: Because we do not add water to our juices the pH remains acidic 4.7 - 5.2. Watered down products do not have this natural bitter property that aids in digestion so remarkably! Best to take the juices a little before a meal. If this is not possible anytime will give good support. For some individuals if taken before bedtime it will keep them awake because of the nutritional factors. For others it has been a wonder aid in a more restful sleep.

Q: How can you best describe the concentration of the Aloe Life juice?
A: We take 1 gallon of fresh ground Whole Leaf Aloe Vera juice and remove 3 quarts of natural occurring water. This gives Aloe Life 1 quart of Aloe Gold, referred to as a 3:1 concentrate.

Q: Is it safe to give Aloe Gold, Aloe juice to dogs? I saw the Aloe Vera Plant listed under poisonous plants on an animal web site?
Yes, it is 100% safe to give to pets. Just start with 1 oz. and increase giving it in increments throughout the day. If diarrhea cut back. Dogs need about 1 oz. per 10 lbs of body weight to increase immune function. What is pretty ridiculous is dogs would never just start eating away on a whole Aloe Vera plant because it is toooo bitter. A little goes a long way. The plant is NOT toxic so they do not know what they are talking about as is the case when people are warned against Aloe Vera. If people get diarrhea they also need to just cut the amount consumed down. It is like Vitamin C. C will cause loose stool if you consume too much at one time. It is, however, NOT toxic.

References

  1. ^ a b c d Ryan KJ, Ray CG (editors) (2004). Sherris Medical Microbiology (4th ed.). McGraw Hill. pp. 555–62. ISBN 0838585299. 
  2. ^ "Herpes simplex". DermNet NZ — New Zealand Dermatological Society. 2006-09-16. http://www.dermnetnz.org/viral/herpes-simplex.html. Retrieved 2006-10-15. 
  3. ^ a b Gupta R, Warren T, Wald A (2007). "Genital herpes". Lancet 370 (9605): 2127–37. doi:10.1016/S0140-6736(07)61908-4. PMID 18156035. 
  4. ^ a b c Koelle DM, Corey L (2008). "Herpes simplex: insights on pathogenesis and possible vaccines". Annual Review of Medicine 59: 381–95. doi:10.1146/annurev.med.59.061606.095540. PMID 18186706. 
  5. ^ Corey L, Wald A (2009). "Maternal and Neonatal Herpes Simplex Virus Infections". New England Journal of Medicine 361 (14): 1376–85. doi:10.1056/NEJMra0807633. PMID 19797284. 
  6. ^ Kimberlin DW (2007). "Herpes simplex virus infections of the newborn". Semin. Perinatol. 31 (1): 19–25. doi:10.1053/j.semperi.2007.01.003. PMID 17317423. 
  7. ^ a b Mettenleiter TC, Klupp BG, Granzow H (2006). "Herpesvirus assembly: a tale of two membranes". Curr. Opin. Microbiol. 9 (4): 423–9. doi:10.1016/j.mib.2006.06.013. PMID 16814597. 
  8. ^ a b c d e McGeoch DJ, Rixon FJ, Davison AJ (2006). "Topics in herpesvirus genomics and evolution". Virus Res. 117 (1): 90–104. doi:10.1016/j.virusres.2006.01.002. PMID 16490275. 
  9. ^ Rajcáni J, Andrea V, Ingeborg R (2004). "Peculiarities of herpes simplex virus (HSV) transcription: an overview". Virus Genes 28 (3): 293–310. doi:10.1023/B:VIRU.0000025777.62826.92. PMID 15266111. 
  10. ^ Search in UniProt Knowledgebase (Swiss-Prot and TrEMBL) for: HHV1
  11. ^ a b Matis J, Kúdelová M (2001). "Early shutoff of host protein synthesis in cells infected with herpes simplex viruses". Acta Virol. 45 (5-6): 269–77. PMID 12083325. 
  12. ^ Wyrwicz LS, Ginalski K, Rychlewski L (2007). "HSV-1 UL45 encodes a carbohydrate binding C-type lectin protein". Cell Cycle 7 (2): 269–71. doi:10.4161/cc.7.2.5324. PMID 18256535. 
  13. ^ Vittone V, Diefenbach E, Triffett D, Douglas MW, Cunningham AL, Diefenbach RJ (2005). "Determination of interactions between tegument proteins of herpes simplex virus type 1". J. Virol. 79 (15): 9566–71. doi:10.1128/JVI.79.15.9566-9571.2005. PMID 16014918. 
  14. ^ a b Subramanian RP, Geraghty RJ (2007). "Herpes simplex virus type 1 mediates fusion through a hemifusion intermediate by sequential activity of glycoproteins D, H, L, and B". Proc. Natl. Acad. Sci. U.S.A. 104 (8): 2903–8. doi:10.1073/pnas.0608374104. PMID 17299053. 
  15. ^ Cardone G, Winkler DC, Trus BL, Cheng N, Heuser JE, Newcomb WW, Brown JC, Steven AC (May 2007). "Visualization of the herpes simplex virus portal in situ by cryo-electron tomography". Virology 361 (2): 426–34. doi:10.1016/j.virol.2006.10.047. PMID 17188319. 
  16. ^ Trus BL, Cheng N, Newcomb WW, Homa FL, Brown JC, Steven AC (November 2004). "Structure and polymorphism of the UL6 portal protein of herpes simplex virus type 1". Journal of Virology 78 (22): 12668–71. doi:10.1128/JVI.78.22.12668-12671.2004. PMID 15507654. 
  17. ^ Nellissery JK, Szczepaniak R, Lamberti C, Weller SK (2007-06-20). "A putative leucine zipper within the HSV-1 UL6 protein is required for portal ring formation". Journal Virology 81 (17): 8868–77. doi:10.1128/JVI.00739-07. PMID 17581990. 
  18. ^ Newcomb WW, Booy FP, Brown JC (2007). "Uncoating the herpes simplex virus genome". J. Mol. Biol. 370 (4): 633–42. doi:10.1016/j.jmb.2007.05.023. PMID 17540405. 
  19. ^ Abbas et al (2009) Cellular and Molecular Immunology, Elsevier Inc.
  20. ^ Adang LA, Parsons CH, Kedes DH (2006). "Asynchronous progression through the lytic cascade and variations in intracellular viral loads revealed by high-throughput single-cell analysis of Kaposi's sarcoma-associated herpesvirus infection". J. Virol. 80 (20): 10073–82. doi:10.1128/JVI.01156-06. PMID 17005685. 
  21. ^ Taddeo B, Roizman B (2006). "The virion host shutoff protein (UL41) of herpes simplex virus 1 is an endoribonuclease with a substrate specificity similar to that of RNase A". J. Virol. 80 (18): 9341–5. doi:10.1128/JVI.01008-06. PMID 16940547. 
  22. ^ Skepper JN, Whiteley A, Browne H, Minson A (June 2001). "Herpes simplex virus nucleocapsids mature to progeny virions by an envelopment --> deenvelopment --> reenvelopment pathway". J. Virol. 75 (12): 5697–702. doi:10.1128/JVI.75.12.5697-5702.2001. PMID 11356979. 
  23. ^ Granzow H, Klupp BG, Fuchs W, Veits J, Osterrieder N, Mettenleiter TC (April 2001). "Egress of alphaherpesviruses: comparative ultrastructural study". J. Virol. 75 (8): 3675–84. doi:10.1128/JVI.75.8.3675-3684.2001. PMID 11264357. 
  24. ^ a b Pinnoji RC, Bedadala GR, George B, Holland TC, Hill JM, Hsia SC (2007). "Repressor element-1 silencing transcription factor/neuronal restrictive silencer factor (REST/NRSF) can regulate HSV-1 immediate-early transcription via histone modification". Virol. J. 4: 56. doi:10.1186/1743-422X-4-56. PMID 17555596. 
  25. ^ Bedadala GR, Pinnoji RC, Hsia SC (2007). "Early growth response gene 1 (Egr-1) regulates HSV-1 ICP4 and ICP22 gene expression". Cell Res. 17 (6): 546–55. doi:10.1038/cr.2007.44. PMID 17502875. 
  26. ^ Roizman B, Gu H, Mandel G (2005). "The first 30 minutes in the life of a virus: unREST in the nucleus". Cell Cycle 4 (8): 1019–21. PMID 16082207. 
  27. ^ Vogler BK, Ernst E (October 1999). "Aloe vera: a systematic review of its clinical effectiveness". The British Journal of General Practice 49 (447): 823–8. PMID 10885091. PMC 1313538. http://openurl.ingenta.com/content/nlm?genre=article&issn=0960-1643&volume=49&issue=447&spage=823&aulast=Vogler. 
  28. ^ BioVex initiates Phase 1 Clinical Trial with its genital herpes vaccine, ImmunoVEXHSV2 http://www.biovex.com/03_04_10_Immunovex_trial.html
  29. ^ Middleton PJ, Petric M, Kozak M, Rewcastle NB, McLachlan DR (May 1980). "Herpes-simplex viral genome and senile and presenile dementias of Alzheimer and Pick". Lancet 315 (8176): 1038. doi:10.1016/S0140-6736(80)91490-7. PMID 6103379. 
  30. ^ Dobson CB, Itzhaki RF (1999). "Herpes simplex virus type 1 and Alzheimer's disease". Neurobiol. Aging 20 (4): 457–65. doi:10.1016/S0197-4580(99)00055-X. PMID 10604441. 
  31. ^ Pyles RB (November 2001). "The association of herpes simplex virus and Alzheimer's disease: a potential synthesis of genetic and environmental factors" (PDF). Herpes 8 (3): 64–8. PMID 11867022. http://www.ihmf.com/journal/download/83pyles(64)vol864.pdf. 
  32. ^ Itzhaki RF, Lin WR, Shang D, Wilcock GK, Faragher B, Jamieson GA (January 1997). "Herpes simplex virus type 1 in brain and risk of Alzheimer's disease". Lancet 349 (9047): 241–4. doi:10.1016/S0140-6736(96)10149-5. PMID 9014911